SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and infl...
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation
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Author / Creator
Palomer, Xavier , Román-Azcona, M. Silvia , Pizarro-Delgado, Javier , Planavila, Ana , Villarroya, Francesc , Valenzuela-Alcaraz, Brenda , Crispi, Fátima , Sepúlveda-Martínez, Álvaro , Miguel-Escalada, Irene , Ferrer, Jorge , Nistal, J. Francisco , García, Raquel , Davidson, Mercy M. , Barroso, Emma and Vázquez-Carrera, Manuel
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances. In this study, we investigated the role of SIRT3 in inflammation and fibro...
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Full title
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation
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TN_cdi_proquest_journals_2366596916
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2366596916
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ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-020-0114-1
