B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombinatio...
B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombination and clonal selection in mice
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) were shown capable of secreting high antibody titers. Here, we demonstrate that, upon immunization of mice, adoptively transferred engineered B cells...
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Full title
B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombination and clonal selection in mice
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TN_cdi_proquest_journals_2370238045
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2370238045
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E-ISSN
2692-8205
DOI
10.1101/2020.02.28.970822
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https://www.proquest.com/docview/2370238045?pq-origsite=primo&accountid=13902
