Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibit...
Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Water networks within kinase inhibitor design and more widely within drug discovery are generally poorly understood. The successful targeting of these networks prospectively has great promise for all facets of inhibitor design, including potency and selectivity on target. Here we describe the design and testing of a targeted library of 4-anilinoqui...
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Full title
Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
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TN_cdi_proquest_journals_2373428118
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2373428118
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E-ISSN
2692-8205
DOI
10.1101/2020.03.06.976563
How to access this item
https://www.proquest.com/docview/2373428118?pq-origsite=primo&accountid=13902
