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Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2389386724

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

About this item

Full title

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-04

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Insulin controls glucose uptake into muscle and fat cells by inducing a net redistribution of GLUT4 from intracellular storage to the plasma membrane (PM). The TBC1D4-RAB10 signaling module is required for insulin-stimulated GLUT4 translocation to the PM, although where it intersects GLUT4 traffic was unknown. Here we demonstrate that TBC1D4-RAB10...

Alternative Titles

Full title

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2389386724

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2389386724

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.04.14.040683