The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS a...
The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations
About this item
Full title
Author / Creator
Kim, Jiyeon , Cai, Feng , Ko, Bookyung , Yang, Chendong , Lee, Hyun Min , Nefertiti Muhammad , Li, Kailong , Haloul, Mohamed , Gu, Wen , Faubert, Brandon , Kaushik, Akash K , Cai, Ling , Sahba Kasiri , Marriam, Ummay , Nham, Kien , Girard, Luc , Wang, Hui , Sun, Xiankai , Kim, James , Minna, John , Unsal-Kacmaz, Keziban and Deberardinis, Ralph J
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
In non−small cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumor suppressor STK11 encoding the kinase LKB1 result in aggressive tumors prone to metastasis but with liabilities arising from reprogrammed metabolism. We previously demonstrated perturbed nitrogen metabolism and addiction to an unconventional pathway of pyr...
Alternative Titles
Full title
The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations
Authors, Artists and Contributors
Author / Creator
Cai, Feng
Ko, Bookyung
Yang, Chendong
Lee, Hyun Min
Nefertiti Muhammad
Li, Kailong
Haloul, Mohamed
Gu, Wen
Faubert, Brandon
Kaushik, Akash K
Cai, Ling
Sahba Kasiri
Marriam, Ummay
Nham, Kien
Girard, Luc
Wang, Hui
Sun, Xiankai
Kim, James
Minna, John
Unsal-Kacmaz, Keziban
Deberardinis, Ralph J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2389387298
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2389387298
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.04.13.039669
How to access this item
https://www.proquest.com/docview/2389387298?pq-origsite=primo&accountid=13902
