Transgene integration causes RARB downregulation in homozygous Tg4–42 mice
Transgene integration causes RARB downregulation in homozygous Tg4–42 mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Alzheimer’s disease can be modelled by different transgenic mouse strains. To gain deeper insight into disease model mechanisms, the previously described Tg4–42 mouse was analysed for transgene integration. On RNA/DNA level the transgene integration resulted in more than 20 copy numbers and further caused a deletion of exon 2 of the retinoic acid r...
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Transgene integration causes RARB downregulation in homozygous Tg4–42 mice
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TN_cdi_proquest_journals_2389697073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2389697073
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-63512-8
