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Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2399021245

Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

About this item

Full title

Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Eukaryotic transcription factors recognize specific DNA sequence motifs, but are also endowed with generic, non-specific DNA-binding activity: how these binding modes are integrated to determine select transcriptional outputs remains unresolved. We designed mutants of the MYC transcription factor bearing substitutions in residues that contact eithe...

Alternative Titles

Full title

Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2399021245

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2399021245

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.05.04.076190