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Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progre...

Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progre...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2400239912

Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progression

About this item

Full title

Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progression

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Background: LIGHT is a member of the TNF superfamily, which has been claimed to mediate anti-tumor activity on the basis of cancer cures observed in immunocompetent mice bearing transgenic LIGHT-expressing tumors. The preclinical development of a LIGHT-based therapeutic has been hindered by the lack of functional stability exhibited by this protein...

Alternative Titles

Full title

Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2400239912

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2400239912

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.05.08.084277