Is there a Future for CYP1A2 Pharmacogenetics in the Optimal Dosing of Clozapine?
Is there a Future for CYP1A2 Pharmacogenetics in the Optimal Dosing of Clozapine?
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Publisher
England: Future Medicine Ltd
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English
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England: Future Medicine Ltd
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The polycyclic aromatic hydrocarbons present in tobacco smoke bind to a nuclear receptor called the aryl hydrocarbon receptor which induces CYP1A2 expression. Geriatric age, which is associated with decreased renal function, probably decreases the clearance of NCLO and other hydrophilic metabolites (2). Zanger and Schwab also suggested that other u...
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Is there a Future for CYP1A2 Pharmacogenetics in the Optimal Dosing of Clozapine?
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TN_cdi_proquest_journals_2403756019
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2403756019
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ISSN
1462-2416
E-ISSN
1744-8042
DOI
10.2217/pgs-2020-0015
