Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntingt...
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington's disease (HD), but the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-seq), we show that the huntingtin protein (HTT) reproducibly occupies specific locations in the mouse genome. More...
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Full title
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models
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TN_cdi_proquest_journals_2409777152
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2409777152
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E-ISSN
2692-8205
DOI
10.1101/2020.06.04.132571
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https://www.proquest.com/docview/2409777152?pq-origsite=primo&accountid=13902
