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A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain

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A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2410192265

A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain

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Publisher

Frankfurt: EMBO Press

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Scope and Contents

Contents

Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we developed a cell‐permeable, high‐affinity (~2 nM) peptide inhibitor, Tat‐P4‐(C5)2, of the PDZ domain protein PIC...

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Full title

A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain

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Record Identifier

TN_cdi_proquest_journals_2410192265

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2410192265

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ISSN

1757-4676

E-ISSN

1757-4684

DOI

10.15252/emmm.201911248

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