Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide c...
Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Nonalcoholic fatty liver disease (NAFLD) affects ~88% of obese individuals and is characterised by hepatic lipid accumulation. Mitochondrial metabolic dysfunction is a feature of NAFLD. We used a human pluripotent stem cell-based system to determine how mitochondrial dysfunction is linked to hepatic lipid accumulation. We induced lipid accumulation...
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Full title
Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation
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TN_cdi_proquest_journals_2416740424
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2416740424
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E-ISSN
2692-8205
DOI
10.1101/2020.06.23.166728
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https://www.proquest.com/docview/2416740424?pq-origsite=primo&accountid=13902
