The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
RNA polymerases (RNAPs) synthesize RNA from NTPs, whereas DNA polymerases synthesize DNA from 2'dNTPs. DNA polymerases select against NTPs by using steric gates to exclude the 2'OH, but RNAPs have to employ alternative selection strategies. In single-subunit RNAPs, a conserved Tyr residue discriminates against 2'dNTPs, whereas selectivity mechanism...
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Full title
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
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TN_cdi_proquest_journals_2419230845
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2419230845
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E-ISSN
2692-8205
DOI
10.1101/2020.06.30.179606
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https://www.proquest.com/docview/2419230845?pq-origsite=primo&accountid=13902
