6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essential for viral polyprotein cleavage and for deconjugation of ISG15, an antiviral ubiquitin-like protei...
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Full title
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
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Record Identifier
TN_cdi_proquest_journals_2419560010
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2419560010
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E-ISSN
2692-8205
DOI
10.1101/2020.07.01.183020
