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Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regu...

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regu...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2424571290

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

About this item

Full title

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

ABSTRACT The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell niches and that this activity affects their p...

Alternative Titles

Full title

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2424571290

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2424571290

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.07.17.208264