Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and an...
Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
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Author / Creator
Olagnier, David , Farahani, Ensieh , Thyrsted, Jacob , Cadanet, Julia B , Herengt, Angela , Idorn, Manja , Hait, Alon , Hernaez, Bruno , Knudsen, Alice , Marie Beck Iversen , Schilling, Mirjam , Jorgensen, Sofie E , Thomsen, Michelle , Reinert, Line , Lappe, Michael , Huy-Dung Hoang , Gilchrist, Victoria H , Hansen, Anne-Louise , Ottosen, Rasmus , Gunderstofte, Camilla , Moller, Charlotte , Demi Van Der Horst , Peri, Suraj , Balachandran, Siddarth , Huang, Jinrong , Jakobsen, Martin , Svenningsen, Esben B , Poulsen, Thomas B , Bartsch, Lydia , Thielke, Anne L , Luo, Yonglun , Alain, Tommy , Rehwinkel, Jan , Alcami, Antonio , Hiscott, John , Mogensen, Trine , Paludan, Soren R and Holm, Christian K
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that the NRF2 anti-oxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-O...
Alternative Titles
Full title
Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Authors, Artists and Contributors
Author / Creator
Farahani, Ensieh
Thyrsted, Jacob
Cadanet, Julia B
Herengt, Angela
Idorn, Manja
Hait, Alon
Hernaez, Bruno
Knudsen, Alice
Marie Beck Iversen
Schilling, Mirjam
Jorgensen, Sofie E
Thomsen, Michelle
Reinert, Line
Lappe, Michael
Huy-Dung Hoang
Gilchrist, Victoria H
Hansen, Anne-Louise
Ottosen, Rasmus
Gunderstofte, Camilla
Moller, Charlotte
Demi Van Der Horst
Peri, Suraj
Balachandran, Siddarth
Huang, Jinrong
Jakobsen, Martin
Svenningsen, Esben B
Poulsen, Thomas B
Bartsch, Lydia
Thielke, Anne L
Luo, Yonglun
Alain, Tommy
Rehwinkel, Jan
Alcami, Antonio
Hiscott, John
Mogensen, Trine
Paludan, Soren R
Holm, Christian K
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2424571883
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2424571883
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2020.07.16.206458
