Plasma Renin Measurements are Unrelated to Mineralocorticoid Replacement Dose in Patients With Prima...
Plasma Renin Measurements are Unrelated to Mineralocorticoid Replacement Dose in Patients With Primary Adrenal Insufficiency
About this item
Full title
Author / Creator
Pofi, Riccardo , Prete, Alessandro , Thornton-Jones, Vivien , Bryce, Jillian , Ali, Salma R , Faisal Ahmed, S , Balsamo, Antonio , Baronio, Federico , Cannuccia, Amalia , Guven, Ayla , Guran, Tulay , Darendeliler, Feyza , Higham, Claire , Bonfig, Walter , de Vries, Liat , Bachega, Tania A S S , Miranda, Mirela C , Mendonca, Berenice B , Iotova, Violeta , Korbonits, Màrta , Krone, Nils P , Krone, Ruth , Lenzi, Andrea , Arlt, Wiebke , Ross, Richard J , Isidori, Andrea M and Tomlinson, Jeremy W
Publisher
US: Oxford University Press
Journal title
Language
English
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Publication information
Publisher
US: Oxford University Press
Subjects
More information
Scope and Contents
Contents
Abstract
Context
No consensus exists for optimization of mineralocorticoid therapy in patients with primary adrenal insufficiency.
Objective
To explore the relationship between mineralocorticoid (MC) replacement dose, plasma renin concentration (PRC), and clinically important variables to determine which are most helpful in guiding MC dose titration in primary adrenal insufficiency.
Design
Observational, retrospective, longitudinal analysis.
Patients
A total of 280 patients (with 984 clinical visits and plasma renin measurements) with primary adrenal insufficiency were recruited from local databases and the international congenital adrenal hyperplasia (CAH) registry (www.i-cah.org). Thirty-seven patients were excluded from the final analysis due to incomplete assessment. Data from 204 patients with salt-wasting CAH (149 adults and 55 children) and 39 adult patients with Addison disease (AD) were analysed.
Main outcome measures
PRC, electrolytes, blood pressure (BP), and anthropometric parameters were used to predi...
Alternative Titles
Full title
Plasma Renin Measurements are Unrelated to Mineralocorticoid Replacement Dose in Patients With Primary Adrenal Insufficiency
Authors, Artists and Contributors
Author / Creator
Prete, Alessandro
Thornton-Jones, Vivien
Bryce, Jillian
Ali, Salma R
Faisal Ahmed, S
Balsamo, Antonio
Baronio, Federico
Cannuccia, Amalia
Guven, Ayla
Guran, Tulay
Darendeliler, Feyza
Higham, Claire
Bonfig, Walter
de Vries, Liat
Bachega, Tania A S S
Miranda, Mirela C
Mendonca, Berenice B
Iotova, Violeta
Korbonits, Màrta
Krone, Nils P
Krone, Ruth
Lenzi, Andrea
Arlt, Wiebke
Ross, Richard J
Isidori, Andrea M
Tomlinson, Jeremy W
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2431030689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2431030689
Other Identifiers
ISSN
0021-972X
E-ISSN
1945-7197
DOI
10.1210/clinem/dgz055
