Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant...
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been investigated in diverse diseases
1
, including steroid-resistant acute graft versus host disease (SR-aGvHD)
2
. However, conventional manufacturing approaches are hampered by challenges with scalability and interdonor variability, and clinical trials ha...
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Full title
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study
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TN_cdi_proquest_journals_2473210325
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2473210325
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-020-1050-x
