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Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase,...

Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase,...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2473271108

Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway

About this item

Full title

Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2020-11, Vol.10 (1), p.20813-20813, Article 20813

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

M. tuberculosis
GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose biosynthetic pathway. The D-glycero-α-D-manno-heptose is a major constituent of lipopolysaccharide and contributes to virulence and antibiotic resistance to mycobacteria. In curren...

Alternative Titles

Full title

Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2473271108

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2473271108

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-020-77230-8

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