Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutiv...
Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO)
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New York: Elsevier Inc
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English
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New York: Elsevier Inc
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The hedgehog signaling pathway is a vital factor for embryonic development and stem cell maintenance. Dysregulation of its function results in tumor initiation and progression. The aim of this research was to establish a disease model of hedgehog-related tumorigenesis with Gorlin syndrome-derived induced pluripotent stem cells (GS-iPSCs). Induced n...
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Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO)
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TN_cdi_proquest_journals_2474980773
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2474980773
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ISSN
0023-6837
E-ISSN
1530-0307
DOI
10.1038/s41374-019-0346-2
