Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymp...
Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor
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Author / Creator
Njeru, Sospeter N. , Kraus, Johann , Meena, Jitendra K. , Lechel, André , Katz, Sarah-Fee , Kumar, Mukesh , Knippschild, Uwe , Azoitei, Anca , Wezel, Felix , Bolenz, Christian , Leithäuser, Frank , Gollowitzer, André , Omrani, Omid , Hoischen, Christian , Koeberle, Andreas , Kestler, Hans A. , Günes, Cagatay and Rudolph, K. Lenhard
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aneuploidy can instigate tumorigenesis. However, mutations in genes that control chromosome segregation are rare in human tumors as these mutations reduce cell fitness. Screening experiments indicate that the knockdown of multiple classes of genes that are not directly involved in chromosome segregation can lead to aneuploidy induction. The possibl...
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Full title
Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor
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TN_cdi_proquest_journals_2476736309
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476736309
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-019-1073-2
