LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppres...
LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas
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Author / Creator
Li, Wenjiao , Dai, Yuan , Shi, Boyun , Yue, Fei , Zou, Jing , Xu, Guibin , Jiang, Xianhan , Wang, Fen , Zhou, Xinke and Liu, Leyuan
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutants in the gene encoding mitochondrion-associated protein LRPPRC were found to be associated with French Canadian Type Leigh syndrome, a human disorder characterized with neurodegeneration and cytochrome c oxidase deficiency. LRPPRC interacts with one of microtubule-associated protein family MAP1S that promotes autophagy initiation and maturati...
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Full title
LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas
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TN_cdi_proquest_journals_2476738727
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476738727
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1257-9
