Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via de...
Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
About this item
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Author / Creator
Xu, Zhanzhan , Li, Xiaoman , Li, Hanxiao , Nie, Chen , Liu, Wanchang , Li, Shiwei , Liu, Zelin , Wang, Weibin and Wang, Jiadong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Multiple RNA processing events including transcription, mRNA splicing, and export are delicately coordinated by the TREX complex. As one of the essential subunits, DDX39B couples the splicing and export machineries by recruiting ALYREF onto mRNA. In this study, we further explore the functions of DDX39B in handling damaged DNA, and unexpectedly fin...
Alternative Titles
Full title
Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
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Record Identifier
TN_cdi_proquest_journals_2476739086
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476739086
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-01482-x
