Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
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Author / Creator
Zhang, Xiaohui , Zhu, Biyun , Chen, Liang , Xie, Ling , Yu, Weishi , Wang, Ying , Li, Linxi , Yin, Shuming , Yang, Lei , Hu, Handan , Han, Honghui , Li, Yongmei , Wang, Liren , Chen, Geng , Ma, Xueyun , Geng, Hongquan , Huang, Wanfeng , Pang, Xiufeng , Yang, Zuozhen , Wu, Yuxuan , Siwko, Stefan , Kurita, Ryo , Nakamura, Yukio , Yang, Li , Liu, Mingyao and Li, Dali
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Although base editors are useful tools for precise genome editing, current base editors can only convert either adenines or cytosines. We developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing both deaminases with a Cas9 nickase to achieve C-to-T and A-to-G conversions at the same target site. Compared to single base editors, A&C-B...
Alternative Titles
Full title
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Authors, Artists and Contributors
Author / Creator
Zhu, Biyun
Chen, Liang
Xie, Ling
Yu, Weishi
Wang, Ying
Li, Linxi
Yin, Shuming
Yang, Lei
Hu, Handan
Han, Honghui
Li, Yongmei
Wang, Liren
Chen, Geng
Ma, Xueyun
Geng, Hongquan
Huang, Wanfeng
Pang, Xiufeng
Yang, Zuozhen
Wu, Yuxuan
Siwko, Stefan
Kurita, Ryo
Nakamura, Yukio
Yang, Li
Liu, Mingyao
Li, Dali
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2476739367
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476739367
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-020-0527-y
