Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion in the huntingtin gene (
HTT
) and involves a complex web of pathogenic mechanisms. Mutant HTT (mHTT) disrupts transcription, interferes with immune and mitochondrial function, and is aberrantly modified post-translationally. Evidence suggests that the mHTT...
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Full title
Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
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TN_cdi_proquest_journals_2476739892
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476739892
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ISSN
1759-4758
E-ISSN
1759-4766
DOI
10.1038/s41582-020-0389-4
