Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positiv...
Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Fusion genes resulting from chromosomal rearrangements are frequently found in a variety of cancer cells. Some of these are known to be driver oncogenes, such as
BCR-ABL
in chronic myelogenous leukemia (CML). The products of such fusion genes are abnormal proteins that are ordinarily degraded in cells by a mechanism known as protein quality c...
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Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells
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TN_cdi_proquest_journals_2476741667
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476741667
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1253-0
