Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induc...
Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction
About this item
Full title
Author / Creator
Tian, Yuanyuan , Meng, Lijun , Wang, Ying , Li, Bohan , Yu, Hongshuang , Zhou, Yan , Bui, Tien , Abraham, Ciril , Li, Alicia , Zhang, Yongping , Wang, Jian , Zhao, Chenchen , Mineishi, Shin , Gallucci, Stefania , Porter, David , Hexner, Elizabeth , Zheng, Hong , Zhang, Yanyun , Hu, Shaoyan and Zhang, Yi
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Graft-versus-host disease (GVHD) causes failed reconstitution of donor plasmacytoid dendritic cells (pDCs) that are critical for immune protection and tolerance. We used both murine and human systems to uncover the mechanisms whereby GVHD induces donor pDC defects. GVHD depleted Flt3-expressing donor multipotent progenitors (MPPs) that sustained pD...
Alternative Titles
Full title
Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2476869341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2476869341
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI136774.
