Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its structural conformation changing more than twice on the...
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Full title
Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
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TN_cdi_proquest_journals_2485937308
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2485937308
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ISSN
1226-3613,2092-6413
E-ISSN
2092-6413
DOI
10.1038/s12276-021-00555-5
