Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppr...
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity
About this item
Full title
Author / Creator
Kim, Dong-Gyun , Cho, Sujin , Lee, Kyu-Yeon , Cheon, Seung-Ho , Yoon, Hye-Jin , Lee, Joo-Youn , Kim, Dongyoon , Shin, Kwang-Soo , Koh, Choong-Hyun , Koo, Ji Sung , Choi, Yuri , Lee, Hyung Ho , Oh, Yu-Kyoung , Jeong, Yoo-Seong , Chung, Suk-Jae , Baek, Moonkyu , Jung, Kwan-Young , Lim, Hyo Jin , Kim, Hyoun Sook , Park, Sung Jean , Lee, Jeong-Yeon , Lee, Sang Jae and Lee, Bong-Jin
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
NAD(P)-dependent steroid dehydrogenase-like (NSDHL), an essential enzyme in human cholesterol synthesis and a regulator of epidermal growth factor receptor (EGFR) trafficking pathways, has attracted interest as a therapeutic target due to its crucial relevance to cholesterol-related diseases and carcinomas. However, the development of pharmacologic...
Alternative Titles
Full title
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity
Authors, Artists and Contributors
Author / Creator
Cho, Sujin
Lee, Kyu-Yeon
Cheon, Seung-Ho
Yoon, Hye-Jin
Lee, Joo-Youn
Kim, Dongyoon
Shin, Kwang-Soo
Koh, Choong-Hyun
Koo, Ji Sung
Choi, Yuri
Lee, Hyung Ho
Oh, Yu-Kyoung
Jeong, Yoo-Seong
Chung, Suk-Jae
Baek, Moonkyu
Jung, Kwan-Young
Lim, Hyo Jin
Kim, Hyoun Sook
Park, Sung Jean
Lee, Jeong-Yeon
Lee, Sang Jae
Lee, Bong-Jin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2486883464
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2486883464
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-020-03490-2
