Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice
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Author / Creator
Nguyen, Quang Linh , Okuno, Noriko , Hamashima, Takeru , Dang, Son Tung , Fujikawa, Miwa , Ishii, Yoko , Enomoto, Atsushi , Maki, Takakuni , Nguyen, Hoang Ngoc , Nguyen, Van Tuyen , Fujimori, Toshihiko , Mori, Hisashi , Andrae, Johanna , Betsholtz, Christer , Takao, Keizo , Yamamoto, Seiji and Sasahara, Masakiyo
Publisher
Dordrecht: Springer Netherlands
Journal title
Language
English
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Publication information
Publisher
Dordrecht: Springer Netherlands
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Scope and Contents
Contents
Blood–brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological diseases. Platelet-derived growth factor receptor-alpha (PDGFRα) induces hemorrhagic transformation (HT) downstream of tissue plasminogen activator in thrombolytic therapy of acute stroke. Thus, PDGFs are attractive therapeutic targets for BBB dysfunction. In the...
Alternative Titles
Full title
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice
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Record Identifier
TN_cdi_proquest_journals_2494717432
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2494717432
Other Identifiers
ISSN
0969-6970,1573-7209
E-ISSN
1573-7209
DOI
10.1007/s10456-020-09742-w
