Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic...
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development
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Author / Creator
Lin, Dawn S. , Tian, Luyi , Tomei, Sara , Amann-Zalcenstein, Daniela , Baldwin, Tracey M. , Weber, Tom S. , Schreuder, Jaring , Stonehouse, Olivia J. , Rautela, Jai , Huntington, Nicholas D. , Taoudi, Samir , Ritchie, Matthew E. , Hodgkin, Philip D. , Ng, Ashley P. , Nutt, Stephen L. and Naik, Shalin H.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Regulation of haematopoietic stem and progenitor cell (HSPC) fate is crucial during homeostasis and under stress conditions. Here we examine the aetiology of the Flt3 ligand (Flt3L)-mediated increase of type 1 conventional dendritic cells (cDC1s). Using cellular barcoding we demonstrate this occurs through selective clonal expansion of HSPCs that a...
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Full title
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development
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TN_cdi_proquest_journals_2501357460
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2501357460
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00636-7
