Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial
Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial
About this item
Full title
Author / Creator
Bragagnoli, Arinilda Campos , Araujo, Raphael L. C. , Ferraz, Mauricio Wagner , dos Santos, Lucas Vieira , Abdalla, Kathia Cristina , Comar, Fabiana , Santos, Florinda Almeida , Oliveira, Marco Antonio , Carvalheira, José Barreto Campello , Cárcano, Flávio Mavigner and da Silveira Nogueira Lima, João Paulo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Patients with refractory colorectal (CRC) cancer have few treatment options. This trial tests the combination of metformin and irinotecan in this setting.
Methods
A phase 2 single-arm trial was conducted, patients received metformin 2500 mg orally a day plus irinotecan 125 mg/m
2
intravenously weekly D1 and D8 every 21 day...
Alternative Titles
Full title
Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2501357540
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2501357540
Other Identifiers
ISSN
0007-0920,1532-1827
E-ISSN
1532-1827
DOI
10.1038/s41416-020-01208-6
