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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2503048672

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

About this item

Full title

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Cancer Immunology, Immunotherapy, 2021-04, Vol.70 (4), p.1101-1113

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Although immunotherapy has achieved impressive durable clinical responses, many cancers respond only temporarily or not at all to immunotherapy. To find novel, targetable mechanisms of resistance to immunotherapy, patient-derived melanoma cell lines were transduced with 576 open reading frames, or exposed to arrayed libraries of 850 bioactive compo...

Alternative Titles

Full title

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2503048672

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2503048672

Other Identifiers

ISSN

0340-7004,1432-0851

E-ISSN

1432-0851

DOI

10.1007/s00262-020-02748-9

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