DNA replication during acute MEK inhibition drives acquisition of resistance through amplification o...
DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing is poorly understood. Here, we investigate BRAFV600E amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205 cells, a well-characterised model for reproducible em...
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Full title
DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene
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TN_cdi_proquest_journals_2504847085
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2504847085
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E-ISSN
2692-8205
DOI
10.1101/2021.03.23.436572
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https://www.proquest.com/docview/2504847085?pq-origsite=primo&accountid=13902
