Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
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Author / Creator
Napolitano, Valeria , Dabrowska, Agnieszka , Schorpp, Kenji , Mourão, André , Barreto-Duran, Emilia , Benedyk, Malgorzata , Botwina, Pawel , Brandner, Stefanie , Bostock, Mark , Chykunova, Yuliya , Czarna, Anna , Dubin, Grzegorz , Fröhlich, Tony , Hoelscher, Michael , Jedrysik, Malwina , Matsuda, Alex , Owczarek, Katarzyna , Pachota, Magdalena , Plettenburg, Oliver , Potempa, Jan , Rothenaigner, Ina , Schlauderer, Florian , Szczepanski, Artur , Kristin Greve-Isdahl Mohn , Blomberg, Bjorn , Sattler, Michael , Hadian, Kamyar , Popowicz, Grzegorz Maria and Pyrc, Krzysztof
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
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Contents
Summary The COVID-19 pandemic caused by SARS-CoV-2 has been socially and economically devastating. Despite an unprecedented research effort, effective therapeutics are still missing to limit severe disease and mortality. Using high-throughput screening, we identified acriflavine as a potent papain-like protease (PLpro) inhibitor. NMR titrations and...
Alternative Titles
Full title
Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Authors, Artists and Contributors
Author / Creator
Dabrowska, Agnieszka
Schorpp, Kenji
Mourão, André
Barreto-Duran, Emilia
Benedyk, Malgorzata
Botwina, Pawel
Brandner, Stefanie
Bostock, Mark
Chykunova, Yuliya
Czarna, Anna
Dubin, Grzegorz
Fröhlich, Tony
Hoelscher, Michael
Jedrysik, Malwina
Matsuda, Alex
Owczarek, Katarzyna
Pachota, Magdalena
Plettenburg, Oliver
Potempa, Jan
Rothenaigner, Ina
Schlauderer, Florian
Szczepanski, Artur
Kristin Greve-Isdahl Mohn
Blomberg, Bjorn
Sattler, Michael
Hadian, Kamyar
Popowicz, Grzegorz Maria
Pyrc, Krzysztof
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2504852069
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2504852069
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.03.20.436259
How to access this item
https://www.proquest.com/docview/2504852069?pq-origsite=primo&accountid=13902
