Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative an...
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 kinase activity, supporting the therapeutic potential of LRRK2 kinase inhibitors for PD. To better unde...
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Full title
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10
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TN_cdi_proquest_journals_2505396314
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505396314
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E-ISSN
2692-8205
DOI
10.1101/2021.02.23.432545
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https://www.proquest.com/docview/2505396314?pq-origsite=primo&accountid=13902
