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The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppress...

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppress...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505437892

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

About this item

Full title

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract The retinoid X receptor (RXR) agonist bexarotene has recently been shown to promote remyelination in individuals with multiple sclerosis. Murine studies demonstrated that RXR agonists can have anti-inflammatory effects by enhancing the ability of all-trans-retinoic acid (αtRA), the primary active metabolite of vitamin A, to promote T regul...

Alternative Titles

Full title

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2505437892

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505437892

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.02.17.431344