SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in sever...
SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Summary In late 2019 a novel coronavirus (SARS-CoV-2) emerged, and has since caused a global pandemic. Understanding the pathogenesis of COVID-19 disease is necessary to inform development of therapeutics, and management of infected patients. Using scRNAseq of blood drawn from SARS-CoV-2 patients, we asked whether SARS-CoV-2 may exploit immune cells as a ‘Trojan Horse’ to disseminate and access multiple organ systems. Our data suggests that circulating cells are not actively infected with SARS-CoV-2, and do not appear to be a source of viral dissemination. Competing Interest Statement The authors have declared no competing interest. Footnotes * https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE151969 * https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156639 * https://github.com/BiernaskieLab/scRNA-seq-SARS-CoV2-Viremia...
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SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
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TN_cdi_proquest_journals_2505742580
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505742580
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E-ISSN
2692-8205
DOI
10.1101/2021.01.19.427282
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https://www.proquest.com/docview/2505742580?pq-origsite=primo&accountid=13902
