Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model
Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model
About this item
Full title
Author / Creator
Xia, Dan , Lianoglou, Steve , Sandmann, Thomas , Calvert, Meredith , Suh, Jung H , Thomsen, Elliot , Dugas, Jason , Pizzo, Michelle E , Devos, Sarah L , Earr, Timothy K , Chia-Ching, Lin , Davis, Sonnet , Ha, Connie , Nguyen, Hoang , Chau, Roni , Yulyaningsih, Ernie , Solanoy, Hilda , Masoud, Shababa T , Liang, Richard , Lin, Karin , Thorne, Robert G , Garceau, Dylan , Whitesell, Jennifer D , Sasner, Michael , Harris, Julie A , Scearce-Levie, Kimberly , Lewcock, Joseph W , Gilbert Di Paolo and Sanchez, Pascal E
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Abstract Microglial dysfunction is believed to play a pathogenic role in Alzheimer’s disease (AD). Here, we characterize the amyloid-β related pathology and microglial responses in an engineered APP knock-in mouse model of familial AD. This model recapitulates key pathological features of AD such as a progressive accumulation of parenchymal amyloid...
Alternative Titles
Full title
Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model
Authors, Artists and Contributors
Author / Creator
Lianoglou, Steve
Sandmann, Thomas
Calvert, Meredith
Suh, Jung H
Thomsen, Elliot
Dugas, Jason
Pizzo, Michelle E
Devos, Sarah L
Earr, Timothy K
Chia-Ching, Lin
Davis, Sonnet
Ha, Connie
Nguyen, Hoang
Chau, Roni
Yulyaningsih, Ernie
Solanoy, Hilda
Masoud, Shababa T
Liang, Richard
Lin, Karin
Thorne, Robert G
Garceau, Dylan
Whitesell, Jennifer D
Sasner, Michael
Harris, Julie A
Scearce-Levie, Kimberly
Lewcock, Joseph W
Gilbert Di Paolo
Sanchez, Pascal E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2505742752
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505742752
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.01.19.426731
How to access this item
https://www.proquest.com/docview/2505742752?pq-origsite=primo&accountid=13902
