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Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505887486

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

About this item

Full title

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract Lysosomes must maintain integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but whether dedicated programs for maintaining lysosomal membrane int...

Alternative Titles

Full title

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2505887486

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505887486

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.01.04.425106