An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML
An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML
About this item
Full title
Author / Creator
Lin, Shan , Larrue, Clément , Seong, Bo Kyung A , Dharia, Neekesh V , Miljan Kuljanin , Wechsler, Caroline , Kugener, Guillaume , Robichaud, Amanda , Conway, Amy , Mashaka, Thelma N , Mouche, Sarah , Adane, Biniam , Ryan, Jeremy , Mancias, Joseph D , Younger, Scott T , Piccioni, Federica , Lee, Lynn , Wunderlich, Mark , Letai, Anthony , Tamburini, Jérôme and Stegmaier, Kimberly
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Abstract CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancers, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have been performed in vitro, evaluating the physiological relevance of these targets is critical....
Alternative Titles
Full title
An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML
Authors, Artists and Contributors
Author / Creator
Larrue, Clément
Seong, Bo Kyung A
Dharia, Neekesh V
Miljan Kuljanin
Wechsler, Caroline
Kugener, Guillaume
Robichaud, Amanda
Conway, Amy
Mashaka, Thelma N
Mouche, Sarah
Adane, Biniam
Ryan, Jeremy
Mancias, Joseph D
Younger, Scott T
Piccioni, Federica
Lee, Lynn
Wunderlich, Mark
Letai, Anthony
Tamburini, Jérôme
Stegmaier, Kimberly
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2505917295
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505917295
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.12.28.424340
How to access this item
https://www.proquest.com/docview/2505917295?pq-origsite=primo&accountid=13902
