Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. We hypothesized that bortezomib (BTZ) might sensitize GBM cells to TMZ. We examined change in autophagic flux after drug treatments...
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Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
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TN_cdi_proquest_journals_2506027840
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506027840
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E-ISSN
2692-8205
DOI
10.1101/2020.12.20.423718
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https://www.proquest.com/docview/2506027840?pq-origsite=primo&accountid=13902
