In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer...
In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target
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Author / Creator
Wang, Xiaoqing , Tokheim, Collin , Wang, Binbin , Gu, Shengqing Stan , Tang, Qin , Li, Yihao , Traugh, Nicole , Zhang, Yi , Li, Ziyi , Zhang, Boning , Fu, Jingxin , Xiao, Tengfei , Li, Wei , Meyer, Clifford A , Chu, Jun , Jiang, Peng , Cejas, Paloma , Lim, Klothilda , Long, Henry , Brown, Myles and X Shirley Liu
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
in vivo CRISPR knockout (KO) screens in syngeneic TNBC mouse models, we found that inhibition of the E3 ubiquitin ligase Cop1 in cancer cells decreases the secretion of macrophage-associated chemokines, reduces tumor macrophage infiltration, and shows synergy in anti-tumor immunity with ICB. Transcriptomics, epigenomics, and proteomics analyses rev...
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Full title
In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target
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TN_cdi_proquest_journals_2506199480
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506199480
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E-ISSN
2692-8205
DOI
10.1101/2020.12.09.418012
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https://www.proquest.com/docview/2506199480?pq-origsite=primo&accountid=13902
