Profiles of expressed mutations in single cells reveal patterns of tumor evolution and therapeutic i...
Profiles of expressed mutations in single cells reveal patterns of tumor evolution and therapeutic impact of intratumor heterogeneity
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Author / Creator
Farid Rashidi Mehrabadi , Marie, Kerrie L , Perez-Guijarro, Eva , Salem Malikic , Erfan Sadeqi Azer , Yang, Howard H , Kizilkale, Can , Gruen, Charli , Liu, Huaitian , Kelly, Michael C , Marcelus, Christina , Burkett, Sandra , Aydin Buluc , Ergun, Funda , Lee, Maxwell P , Merlino, Glenn , Day, Chi-Ping and Sahinalp, S Cenk
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Advances in single cell RNA sequencing (scRNAseq) technologies uncovered an unexpected complexity in solid tumors, underlining the relevance of intratumor heterogeneity for cancer progression and therapeutic resistance. Heterogeneity in the mutational composition of cancer cells is well captured by tumor phylogenies, which demonstrate how distinct...
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Full title
Profiles of expressed mutations in single cells reveal patterns of tumor evolution and therapeutic impact of intratumor heterogeneity
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TN_cdi_proquest_journals_2506261953
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506261953
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DOI
10.1101/2021.03.26.437185
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https://www.proquest.com/docview/2506261953?pq-origsite=primo&accountid=13902
