Structure and inhibitor binding characterization of oncogenic MLLT1 mutants
Structure and inhibitor binding characterization of oncogenic MLLT1 mutants
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the development of aggressive cancers. Mutations in the YEATS domain have been recently reported as a cause of MLLT1 aberrant reader function. However, structural basis for the reported alterations in affinity for...
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Full title
Structure and inhibitor binding characterization of oncogenic MLLT1 mutants
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TN_cdi_proquest_journals_2506310047
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506310047
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E-ISSN
2692-8205
DOI
10.1101/2021.02.08.430291
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https://www.proquest.com/docview/2506310047?pq-origsite=primo&accountid=13902
