Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease
Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Lafora disease is a fatal progressive myoclonus epilepsy. At root, it is due to constant acquisition of branches that are too long in a subgroup of glycogen molecules, leading them to precipitate and accumulate into Lafora bodies, which drive a neuroinflammatory response and neurodegeneration. As a potential therapy, we aimed to downregula...
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Full title
Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease
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TN_cdi_proquest_journals_2506310073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506310073
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E-ISSN
2692-8205
DOI
10.1101/2021.02.11.430846
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https://www.proquest.com/docview/2506310073?pq-origsite=primo&accountid=13902
