Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
About this item
Full title
Author / Creator
Leppek, Kathrin , Byeon, Gun Woo , Kladwang, Wipapat , Wayment-Steele, Hannah K , Kerr, Craig H , Xu, Adele F , Kim, Do Soon , Topkar, Ved V , Choe, Christian , Rothschild, Daphna , Tiu, Gerald C , Wellington-Oguri, Roger , Fujii, Kotaro , Sharma, Eesha , Watkins, Andrew M , Nicol, John J , Romano, Jonathan , Tunguz, Bojan , Participants, Eterna , Barna, Maria and Das, Rhiju
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we describe design principles that overcome these barriers. We develop a new RNA sequencing-based platform called PERSIST-seq to systematica...
Alternative Titles
Full title
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
Authors, Artists and Contributors
Author / Creator
Byeon, Gun Woo
Kladwang, Wipapat
Wayment-Steele, Hannah K
Kerr, Craig H
Xu, Adele F
Kim, Do Soon
Topkar, Ved V
Choe, Christian
Rothschild, Daphna
Tiu, Gerald C
Wellington-Oguri, Roger
Fujii, Kotaro
Sharma, Eesha
Watkins, Andrew M
Nicol, John J
Romano, Jonathan
Tunguz, Bojan
Participants, Eterna
Barna, Maria
Das, Rhiju
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2507090630
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507090630
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.03.29.437587
