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β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behavior

β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behavior

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507133064

β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behavior

About this item

Full title

β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behavior

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract Astrocytes play essential roles in supporting neuronal activity and synapse formation; however, mechanisms by which these functions are regulated are unclear. The Wnt/β-catenin signaling pathway plays a crucial role in brain development and is implicated in neurodevelopmental disorders including autism spectrum disorder (ASD). We sought to...

Alternative Titles

Full title

β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behavior

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2507133064

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507133064

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.11.28.402099