Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge
Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge
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Yamashita, Daisuke , Botta, Davide , Hee Jin Cho , Guo, Xiaoxian , Ozaki, Saya , Flanary, Victoria L , Sirota, Inna , Gao, Mu , Yamaguchi, Shinobu , Nakano, Mayu A , Zhou, Fen , Zhou, Hongyi , Kondo, Toru , Kunieda, Takeharu , Crossman, David K , Kornblum, Harley I , Gorospe, Myriam , Do-Hyun, Nam , Zamboni, Nicola , Skolnick, Jeffrey , Gu, Zhenglong , Lund, Frances E and Nakano, Ichiro
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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ABSTRACT Even after total resection of glioblastoma core lesions by surgery and aggressive post-surgical treatments, life-threatening tumors inevitably recur. A characteristic obstacle in effective treatment is high intratumoral heterogeneity, both longitudinally and spatially. Recurrence occurs predominantly at the brain parenchyma-tumor core inte...
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Full title
Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge
Authors, Artists and Contributors
Author / Creator
Botta, Davide
Hee Jin Cho
Guo, Xiaoxian
Ozaki, Saya
Flanary, Victoria L
Sirota, Inna
Gao, Mu
Yamaguchi, Shinobu
Nakano, Mayu A
Zhou, Fen
Zhou, Hongyi
Kondo, Toru
Kunieda, Takeharu
Crossman, David K
Kornblum, Harley I
Gorospe, Myriam
Do-Hyun, Nam
Zamboni, Nicola
Skolnick, Jeffrey
Gu, Zhenglong
Lund, Frances E
Nakano, Ichiro
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TN_cdi_proquest_journals_2507133676
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507133676
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E-ISSN
2692-8205
DOI
10.1101/2020.11.26.399725
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https://www.proquest.com/docview/2507133676?pq-origsite=primo&accountid=13902