Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL
Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL
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Author / Creator
Pandey, Suraj , Calvey, George , Katz, Andrea M , Tek, Narsingh Malla , Koua, Faisal H M , Martin-Garcia, Jose M , Poudyal, Ishwor , Jay-How, Yang , Vakili, Mohammad , Yefanov, Oleksandr , Zielinski, Kara A , Bajt, Saša , Awel, Salah , Dörner, Katerina , Frank, Matthias , Gelisio, Luca , Jernigan, Rebecca , Kirkwood, Henry , Kloos, Marco , Koliyadu, Jayanath , Mariani, Valerio , Miller, Mitchell D , Mills, Grant , Nelson, Garrett , Olmos, Jose L , Sadri, Alireza , Sato, Tokushi , Tolstikova, Alexandra , Xu, Weijun , Ourmazd, Abbas , Spence, John H C , Schwander, Peter , Barty, Anton , Chapman, Henry N , Fromme, Petra , Mancuso, Adrian P , Phillips, George N , Bean, Richard , Pollack, Lois and Schmidt, Marius
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Abstract In this study, we follow the diffusion and buildup of occupancy of the substrate ceftriaxone in M. tuberculosis β-lactamase BlaC microcrystals by structural analysis of the enzyme substrate complex at single millisecond time resolution. We also show the binding and the reaction of an inhibitor, sulbactam, on a slower millisecond time scale...
Alternative Titles
Full title
Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL
Authors, Artists and Contributors
Author / Creator
Calvey, George
Katz, Andrea M
Tek, Narsingh Malla
Koua, Faisal H M
Martin-Garcia, Jose M
Poudyal, Ishwor
Jay-How, Yang
Vakili, Mohammad
Yefanov, Oleksandr
Zielinski, Kara A
Bajt, Saša
Awel, Salah
Dörner, Katerina
Frank, Matthias
Gelisio, Luca
Jernigan, Rebecca
Kirkwood, Henry
Kloos, Marco
Koliyadu, Jayanath
Mariani, Valerio
Miller, Mitchell D
Mills, Grant
Nelson, Garrett
Olmos, Jose L
Sadri, Alireza
Sato, Tokushi
Tolstikova, Alexandra
Xu, Weijun
Ourmazd, Abbas
Spence, John H C
Schwander, Peter
Barty, Anton
Chapman, Henry N
Fromme, Petra
Mancuso, Adrian P
Phillips, George N
Bean, Richard
Pollack, Lois
Schmidt, Marius
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2507152851
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507152851
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.11.24.396689
How to access this item
https://www.proquest.com/docview/2507152851?pq-origsite=primo&accountid=13902
